Recent Faculty Accomplishments!

The Cologna group has created visual maps of gangliosides in mouse brain tissue.

Two of our faculty have reported substantial new findings in several publications.

Prof. Stephanie Cologna recently published "Mass Spectrometry Imaging of Lipids: Generation of Untargeted Consensus Spectra Reveals Spatial Distributions in Niemann-Pick Disease, Type C1" in the Journal of Lipid Research. Shown above is an example of their use of mass spectrometry imaging to map lipid distribution in a neurodegenerative disease model.

Talk about retirement? Not to our emeritus Prof. Timothy Keiderling, who published 8 papers in 2018! These include:
1. "Mini review:  Instrumentation for vibrational circular dichroism spectroscopy, still a role for dispersive instruments" Timothy A. Keiderling and Ahmed Lakhani, Chirality30, 238-253 (2018) doi: 10.1002/chir.22799.
2.  "Role of Aromatic Crosslinks in Structure and Dynamics of Model Three-stranded β-Sheet Peptides" Scheerer, David; Chi, Heng; McElheny, Dan; Samer, Ayesha; Keiderling, Timothy; Hauser, Karin, Journal of Physical Chemistry A122, 543-553 (2018) DOI: 10.1021/acs.jpca.7b10190.
3. "Theory of Molecular Vibrational Zeeman Effects as Measured with Circular Dichroism” Timothy A. Keiderling and Petr Bouř,  Physical Review Letters, 121, 073201 (2018) doi: 10.1103/PhysRevLett.121.073201.
4. "Vibrational Circular Dichroism Sheds New Light on the Competitive Effects of Crowding and β‑Synuclein on the Fibrillation Process of α‑Synuclein" Evelien Van de Vondel, Pieter Baatsen, Roos Van Elzen, Anne-Marie Lambeir, Timothy A. Keiderling, Wouter Herrebout, Christian Johannessen, Biochemistry, 57, 5989−5995 (2018). doi:10.1021/acs.biochem.8b00780.
5. Feature Paper: "Focused review: Instrumentation for vibrational circular dichroism spectroscopy, Method comparison and newer developments," Timothy A. Keiderling, Molecules (MDPI), 23, 2404 (2018) doi:10.3390/molecules23092404.
6. "Isotopically Site-Selected Dynamics of a Three-Stranded β-Sheet Peptide Detected with Temperature-Jump IR-Spectroscopy" David Scheerer, Heng Chi, Dan McElheny, Timothy A. Keiderling, Karin Hauser, Journal of Physical Chemistry, 122, 10445-10454 (2018). doi: 10.1021/acs.jpcb.8b08336.
7.  "Vibrational Coupling of Small Molecules with Potential Applications to Determination of Polymer Structures" Allen Walker, Timothy A. Keiderling and Ahmed Lakhani,  Chemical Educator, 23253–260 (2018) foi:10.1333/s00897182831a.
8.  "β2-Type amyloid-like fibrils of poly-L-glutamic acid convert into long uninterrupted helices upon dissolution in dimethyl sulfoxide" Sylwia Berbeć, Robert Dec, Dmitry Molodenskiy, Beata Wielgus-Kutrowska, Christian Johannessen, Agnieszka Hernik-Magoń, Fernando Tobias, Agnieszka Bzowska, Grzegorz Ścibisz, Timothy A. Keiderling, Dmitri Svergun, Wojciech Dzwolak, Journal of Physical Chemistry, 122,  11895-11905 (2018). doi:10.1021/acs.jpcb.8b08308.
Prof. Keiderling also published an Encyclopedia entry:
9. “Quantum mechanical simulations of biopolymer vibrational spectra”, 10 pp, and “Vibrational Circular Dichroism of Biopolymers”, 8 pp, Timothy A. Keiderling,Encyclopedia of Biophysics– revision of two entriesed. Gordon Roberts, (Vibrational Spectroscopy section ed. Andreas Barth), Springer, EBSA, European Biophysical Societies Association (2018). doi:10.1007/978-3-642-35943-9_107-1 and  doi:10.1007/978-3-642-35943-9_125-1.