5417A SES, MC 111
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Our research lay at the interface of analytical chemistry, mass spectrometry, bioengineering, and surface science. We apply advanced instrumental methods to modify and characterize both biological and materials surfaces in several distinct projects. In some cases, this involves the construction of novel instrumentation. Other cases, we use advanced instrumentation located in our laboratory, in UIC’s centralized instrumentation facility known as the Research Resources Center, or in Department of Energy synchrotron radiation research user facilities. Most of these experimental methods involve photon, ion, or cluster interactions with gaseous molecules or solid surfaces that lead to photoionization, photoemission of electrons, laser ablation or sputtering of material from surfaces.
- Laser Desorption Postionization Mass Spectrometric Imaging of Biofilms & Organic Films. Mass spectrometric imaging is used to probe bacterial biofilms, organic semiconductors, mammalian tissues, and other complex molecular surfaces with micron lateral and depth resolution. Molecular and elemental species are detected in intact samples in a method known as laser desorption postionization mass spectrometry (LDPI-MS) imaging. LDPI-MS imaging, matrix-assisted laser desorption ionization mass spectrometry and secondary ion mass spectrometry are all used to probe antibiotics, proteins, peptides, and metabolites within intact biofilms with the ultimate goal of advancing novel biofilm control methods. Bottom up proteomics via traditional methods are also performed for this purpose and to compare with LDPI-MS and other methods.
- Applying Advanced Surface Analysis Methods. Many other methods in advanced surface analysis are also applied to the above problems, including X-ray and ultraviolet photoelectron spectroscopy, near edge X-ray absorption spectroscopy, X-ray surface scattering, transmission and scanning electron microscopy, linear and nonlinear optical absorption of films, quartz crystal microbalance measurement of film deposition or removal, and X-ray diffraction.
Since 2011 only, out of 131 total refereed & 15 non-refereed. Senior author is underlined.
131. “Solid sampling with a diode laser for portable ambient mass spectrometry”, Y.P. Yung, R. Wickramasinghe, A. Vaikkinen, T.J. Kauppila, I.V. Veryovkin, and L. Hanley, Anal. Chem. 89 (2017) 7297-7301. http://dx.doi.org/10.1021/acs.analchem.7b01745, PMCID: PMC5518277
130. “Metal impurity-assisted formation of nanocone arrays on Si by low energy ion-beam irradiation”, K. Steeves Lloyd, I.L. Bolotin, M. Schmeling, L. Hanley, I.V. Veryovkin, Surf. Sci. 652 (2016) 334-343. http://dx.doi.org/10.1016/j.susc.2016.03.016
129. “ChiMS: Open-source instrument control software platform on LabVIEW for imaging/depth profiling mass spectrometers”, Y. Cui and L. Hanley, Rev. Sci. Instrum. 86 (2015) 065106. http://dx.doi.org/10.1063/1.4922913 PMCID: 4482810
128. “High lateral resolution vs. molecular preservation in near-IR fs-laser desorption postionization mass spectrometry" Y. Cui, I.V. Veryovkin, M.W. Majeski, D.R. Cavazos, and L. Hanley, Anal. Chem. 87 (2015) 367-371. http://dx.doi.org/10.1021/ac5041154 (open access)
127. “Internal energy of thermometer ions formed by femtosecond laser desorption: Implications for mass spectrometric imaging”, S. Milasinovic, Y. Cui, R.J. Gordon and L. Hanley, J. Phys. Chem. C 118 (2014) 28938-28947. http://dx.doi.org/10.1021/jp504062u (open access)
126. “Cluster beam deposition of Cu2-XS nanoparticles into organic thin films”, M.W. Majeski, I.L. Bolotin, and L. Hanley, ACS Appl. Mater. Interf. 6 (2014) 12901-12908. http://dx.doi.org/10.1021/am5028428
125. “Ion sources for mass spectrometric identification and imaging of molecular species”, C. Bhardwaj and L. Hanley, Nat. Prod. Rep. 31 (2014) 756-767. http://dx.doi.org/10.1039/C3NP70094A
124. “Differentiation of microbial species and strains in coculture biofilms by multivariate analysis of laser desorption postionization mass spectra”, C. Bhardwaj, Y. Cui, T. Hofstetter, S.Y. Liu, H.C. Bernstein, R.P. Carlson, M. Ahmed, and L. Hanley, Analyst 138 (2013) 6844-6851. http://dx.doi.org/10.1039/C3AN01389H, PMCID: 3833099
123. “Molecular imaging and depth profiling of biomaterials interfaces by femtosecond laser desorption postionization mass spectrometry, Y. Cui, C. Bhardwaj, S. Milasinovic, R.P. Carlson, R.J. Gordon, and L. Hanley, ACS Appl. Mater. Interf. 5 (2013) 9269-9275. http://dx.doi.org/10.1021/am4020633
122. “Laser desorption VUV postionization MS imaging of a cocultured biofilm”, by C. Bhardwaj, J.F. Moore, Y. Cui, G.L. Gasper, H.C. Bernstein, R.P. Carlson, and L. Hanley, Anal. Bioanal. Chem. 405 (2013) 6969-6977. http://dx.doi.org/10.1007/s00216-012-6454-0, PMCID: PMC3566334.
121. “Quantification of antibiotic in biofilm-inhibiting multilayers by 7.87 eV laser desorption postionization MS imaging”, M. Blaze M. T., A. Akhmetov, B. Aydin, P.D. Edirisinghe, G. Uygur, and L. Hanley, Anal. Chem. 84 (2012) 9410-9415. http://dx.doi.org/10.1021/ac302230e, PMCID: 3491138.
120. “Acetylene ion-enhanced bonding of PbS nanoparticles to quaterthiophene in thin films”, by F.D. Pleticha, D. Lee, S.B. Sinnott, I.L. Bolotin, M.W. Majeski, and L. Hanley, J. Phys. Chem. C 116 (2012) 21693-21698. http://dx.doi.org/10.1021/jp306668k
119. “Depth profiling and imaging capabilities of an ultrashort pulse laser ablation time of flight mass spectrometer”, Y. Cui, J.F. Moore, S. Milasinovic, Y. Liu, R.J. Gordon, and L. Hanley, Rev. Sci. Instrum. 83 (2012) 093702. http://dx.doi.org/10.1063/1.4750974, PMCID: PMC3461015
118. “Identification and imaging of peptides and proteins on Enterococcus faecalis biofilms by matrix assisted laser desorption ionization mass spectrometry”, M. Blaze M. T., B. Aydin, R. Carlson, and L. Hanley, Analyst 137 (2012) 5018-5025. http://dx.doi.org/10.1039/C2AN35922G, PMCID: PMC3654527.
117. “Photoresponse of PbS nanoparticle - quaterthiophene films prepared by gaseous deposition as probed by XPS,” M.W. Majeski, F.D. Pleticha, I.L. Bolotin, L. Hanley, E. Yilmaz and S. Suzer, J. Vac. Sci. Technol. 30 (2012) 04D109. http://dx.doi.org/10.1116/1.4709386.
116. “Feasibility of depth profiling of animal tissue by ultrashort pulse laser ablation,” S. Milasinovic, Y. Liu, C. Bhardwaj, M. Blaze M.T., R.J. Gordon and L. Hanley, Anal. Chem. 84 (2012) 3945-3951. http://dx.doi.org/10.1021/ac300557a, PMCID: PMC3371643
115. “Cluster beam deposition of metal, insulator, and semiconductor nanoparticles”, A.M. Zachary, I.L. Bolotin, and L. Hanley, in “Nanofabrication using Focused Ion and Electron Beams: Principles and Applications”, I. Utke, S. Moshkalev, and P. Russell, eds. (Oxford University Press, 2012), 457-485, ISBN: 978-0-19-973421-4.
114. “Brominated tyrosine and polyelectrolyte multilayer analysis by laser desorption VUV postionization and secondary ion mass spectrometry”, M. Blaze M.T., L.K. Takahashi, J. Zhou, M. Ahmed, G.L. Gasper, F.D. Pleticha, and L. Hanley, Anal. Chem. 83 (2011) 4962-4969 http://pubs.acs.org/doi/abs/10.1021/ac200693h, PMCID: PMC3115520
1994-1999, National Science Foundation Young Invest, National Science Foundation
1995-1998, UIC Junior Scholar, UIC
1997, Teaching Recognition Award, UIC
University of Toronto, 1983
PhD, State University of New York at Stony Brook, 1988
NSF Postdoctoral Fellow, University of Pittsburgh, 1988-1990