Analytical


The Analytical Chemistry Division includes several researchers who focus on a wide variety problems in bioanalytical and materials chemistry. Furthermore, several faculty from other divisions contribute effort to the division, include Jordi Cabana, Tim KeiderlingPreston Snee and Michael Trenary.

Stephanie Cologna studies the intersection of chemistry, biology and human medicine. Specifically, she is interested in using state-of-the-art mass spectrometry and allied analytical techniques to answer chemical and biological questions important to understanding and treating human diseases. Mass spectrometry has emerged as a powerful tool to study a range of biomolecules including peptides, proteins, lipids among others.  With recent developments in ionization techniques and mass analyzers, the high-throughput detection and quantification of analytes has become feasible. To this end, she is interested in understanding neurodegenerative disorders including a subset of diseases called lysosomal storage diseases.

Luke Hanley studies a wide array of problems at the interface of surface analysis, biomaterials, and bacterial biofilms. He has been developing new methods of three dimensional imaging of biological materials by laser desorption postionization mass spectrometry and related methods. His work also includes X-ray photoelectron spectroscopy and the application of synchrotron radiation for photoionization and photoemission. His current research projects include surface chemical modification and analysis of biomaterials, probing antimicrobial transport from biomaterials into bacterial biofilms, and development of organic-inorganic nanocomposite films for nonlinear optical and photovoltaic applications.

Scott Shippy develops tools and methods for collection and analysis of volume-limited biological samples. He uses novel fluidic tools to collect nanoliter to microliter samples of extracellular fluid from in vivo animal models and various forms of capillary electrophoresis, microfluidics and mass spectrometry to obtain chemical content information including amino acids, metabolites of nitric oxide and peptides and proteins. His interests are in using the analysis of the blood of individual drosophila (fruit fly) to study circadian rhythms and perfusion sampling of rodent brain or retina to study feeding behavior or diabetic retinopathy. His work also includes a multidisciplinary project to develop an implantable retinal prosthetic that utilizes light driven chemical stimulation.

Yoshitaka Ishii's group aims to play a leading role in development of solid-state NMR (SSNMR) methods and innovative applications of these methods to elucidate structures of interesting biomolecules and nano materials. Novel research targets explored by his group include cytotoxic protein nano-assemblies found in the course of protein misfolding, drugs/proteins coordinated to paramagnetic metal ions, and graphene-related nano materials. His group also aims to solve important biochemical/biophysical problems on proteins and peptides associated with Alzheimer's and other diseases using a variety of techniques such as cell culturing, fluorescence spectroscopy, electron microscopy, and peptide synthesis. Naturally, his research is trans-disciplinary between chemistry, physics, and biology or between analytical chemistry, spectroscopy, and structural biology.