LAS Distinguished Professor
4246 SES, MC 111
Our research group is interested in the discovery of new metal-catalyzed reactions, investigation of their mechanisms and, based on these new reactions, development of novel methodologies for synthetic organic chemistry.
Our first area of interest is concerned with the development of highly selective annulation and benzannulation reactions, catalyzed by late transition metals, particularly palladium. We anticipate an application of these methodologies towards the synthesis of important multifunctional aromatic and heteroaromatic compounds. We have recently discovered a highly chemo- and regioselective palladium-catalyzed intermolecular trimerization of three different alkynes that leads to multifunctional benzenes, thus partly solving the long-standing problem of regioselective intermolecular trimerization of alkynes.
Our second area of interest focuses on the developmentof novel methods for the synthesis of heterocyclic compounds; ubiquitous structural units found in most areas of synthetic organic chemistry, material science and in a wide variety of biologically active and naturally occurring molecules. Development of this area was triggered by our recent discovery of the novel Cu-assisted cycloisomerization of alkynyl imines into pyrroles. The generality and synthetic usefulness of this methodology was demonstrated in the efficient synthesis of pyrroles, various types of fused heteroaromatic compounds, and the expeditious synthesis of (�) monomorine.
A third area of our interest lies in the development of selective Lewis acid-catalyzed carbon-carbon and carbon-heteroatom bond formation and cleavage reactions. We are particularly interested in developing novel functionalization and reduction protocols, which are "truly catalytic" in Lewis acid.
BSc, Kuban State University, 1978
PhD, Latvian Institute of Organic Synthesis, 1984
Group Leader, Latvian Institute of Organic Synthesis, 1986-1991
JSPS Postdoctoral Fellow, Tohoku University, 1992-1993
Ciba-Geigy International Postdoctoral Fellow, Tohoku University, 1993-1994