George A. Papadantonakis
Clinical Professor; Director of General Chemistry; Assistant Head
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About
George Papadantonakis focuses on cancer biophysics. Using ab initio quantum mechanical calculations, we investigate the energetics of DNA damage induced by ultraviolet radiation and methylation. Nucleotide ionization energies provide a quantitative measurement of the electron-donating properties of DNA. Attack of DNA by methylation agents plays a ubiquitous role in mechanisms of chemical carcinogenesis and cancer chemotherapy.