George A. Papadantonakis
Clinical Professor; Director of General Chemistry; Assistant Head
4506 SES, MC 111
George Papadantonakis focuses on cancer biophysics. Using ab initio quantum mechanical calculations, we investigate the energetics of DNA damage induced by ultraviolet radiation and methylation. Nucleotide ionization energies provide a quantitative measurement of the electron-donating properties of DNA. Attack of DNA by methylation agents plays a ubiquitous role in mechanisms of chemical carcinogenesis and cancer chemotherapy.