Catalysis, Synthesis & Drug Development
Introduction
In the ever-evolving realm of catalysis research, multiple teams are driving forward critical advancements. Their collective efforts revolve around exploring novel methodologies to facilitate intricate chemical transformations and promote sustainable synthesis techniques. Further investigations center on the design and implementation of efficient catalytic systems for diverse applications, spanning energy conversion, drug delivery, and environmental sustainability. Concurrently, these groups contribute significantly to the fundamental understanding of surface reactions and their implications in various industrial processes.
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Catalysis research groups
A. Jean-Luc Ayitou
Our laboratory is currently focused on developing new photochemical and photo physical methods and molecular systems for applications that lie at the intersection of:
- Solar energy conversion via non-linear photophysical processes
- Drug discovery and rapid structural derivation of bioactive molecules via metal-free photocatalysis
- Photo-medicinal chemistry
- Photometric sensing of heavy metal ions
- Organic materials for battery applications
Paul R Carlier
- Drug discovery for malaria and multi drug-resistant bacteria
- Development of chemoproteomic probes for drug target identification
- Organic synthesis
Catalysis research groups
Neal Mankad
- What does nature use to catalyze energy conversion reactions?
- How can we replace precious metals with earth-abundant elements?
- How can we improve our energy storage devices?
Justin Mohr
- Transition metal catalysis
- Radical chemistry
- Mechanistic study
- Natural product synthesis
Daesung Lee
- Our research focuses on developing new synthetic methods and applying them to create structurally unique and biologically active natural products, with a specific interest in metal-catalyzed reactions to combine alkenes and alkynes, forming complex unsaturated molecules.
- We are exploring aryne formation from tri- and tetraynes, and utilizing their reactivity for novel transformations, as a significant area of our research.
- Investigating the reaction between lithiated trimethylsilyldiazomethane and unsaturated carbonyl compounds, followed by N–N bond proteolytic cleavage, aims to achieve formal 1,2-aminocyanation, crucial for synthesizing amino quaternary carbon-containing molecules like amathspiramides and massadine.
Alison Ondrus
- Our lab uses a combination of synthetic, biochemical, and genetic tools to define how specific cholesterol metabolites wire and re-wire cellular pathways, with the ultimate goal of translating their structural code into new small molecule therapeutics.
Duncan Wardrop
Two major areas of interest
- Target-directed organic synthesis
- Electron-deficient, divalent reactive intermediates
- Chemistry of nitrenium ions and other electron-deficient nitrogen species
- Alkylidenecarbene generation and applications
- Medicinal chemistry
- Selective HDAC inhibitors to improve cancer immunotherapy