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Photo of Moore, Terry

Terry Moore

Associate Professor

Pharmaceutical Sciences with a courtesy appointment in Chemistry



833 South Wood Street, Rm 504 (MC 781)

Office Phone:

(312) 413-1846

Related Sites:


The work in our lab uses the tools of synthetic medicinal chemistry and chemical biology to develop new tools for studying therapeutically important molecular interactions, with a focus on protein-protein interactions. Our work currently focuses on several different therapeutic targets, including estrogen receptor/coactivator interactions, KEAP1/NRF2 interactions, the bacterial ribosome, and proteins related to entry of influenza, Ebola, and Nipah viruses.


Selected Publications

  1. Lazzara, P. R.; Jain, A. D.; Maldonado, A. C.; Richardson, B. G.; Skowron, K. J.; David, B. P.; Siddiqui, Z.; Ratia, K. M.; Moore, T. W. Synthesis and Evaluation of Non-covalent Naphthalene-Based KEAP1-NRF2 Inhibitor Analogs. ACS Medicinal Chemistry Letters 2020, 11, 521-527.  doi: 10.1021/acsmedchemlett.9b00631.
  2. Lazzara, P. R.; David, B. P.; Ankireddy, A.; Richardson, B. G.; Dye, K.; Ratia, K.; Reddy, S. P.; Moore, T. W. Isoquinoline Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-derived 2)-like 2 (KEAP1-NRF2) Inhibitors with High Metabolic Stability. Journal of Medicinal Chemistry 2020, 63, 6547-6560 doi: 10.1021/acs.jmedchem.9b01074.
  3. Lazzara, P. R.; Moore, T. W. Scaffold-Hopping as a Strategy to Address Metabolic Liabilities of Aromatic Compounds. RSC Medicinal Chemistry 2020, 11, 18–29. doi: 10.1039/C9MD00396G.
  4. Richardson, B. G.; Jain, A. D.; Potteti, H.; Lazzara, P. R.; David, B. P.; Tamatam, C.; Choma, E.; Skowron, K. J.; Dye, K.; Siddiqui, Z.; Wang, Y-. T. Krunic, A.; Reddy, S. P.; Moore, T. W. Replacement of a Naphthalene Scaffold in Kelch-like ECH-Associated Protein 1 (KEAP1)/Nuclear factor (erythroid-derived 2)-like 2 (NRF2) Inhibitors. Journal of Medicinal Chemistry, 2018, 61, 8029–8047. doi: 10.1021/acs.jmedchem.8b01133.


BA, Summa cum laude, Biochemistry
Abilene Christian University, Abilene, TX
PhD, Chemistry
University of Illinois at Urbana-Champaign, Urbana, IL